Evolution of Negative Cooperativity in Glutathione Transferase Enabled Preservation of Enzyme Function
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چکیده
منابع مشابه
Evolution of Negative Cooperativity in Glutathione Transferase Enabled Preservation of Enzyme Function.
Negative cooperativity in enzyme reactions, in which the first event makes subsequent events less favorable, is sometimes well understood at the molecular level, but its physiological role has often been obscure. Negative cooperativity occurs in human glutathione transferase (GST) GSTP1-1 when it binds and neutralizes a toxic nitric oxide adduct, the dinitrosyl-diglutathionyl iron complex (DNDG...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2016
ISSN: 0021-9258
DOI: 10.1074/jbc.m116.749507